EXPERIENCE
- Associate Professor (2024-present), School of Medicine, School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China
- Assistant Professor (2022-2023), School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Postdoctoral Research Scientist (2019-2022), Department of Biostatistics, Columbia University, New York, NY
- Supervisor: Prof. Iuliana Ionita-Laza
EDUCATION
- Ph.D. in Statistics (2019), Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY
- Advisors: Prof. Michael P. McDermott and Prof. David Oakes
- Dissertation: Methods for Improving Efficiency in Clinical Trials
- M.A. in Statistics (2016), Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY
- B.S. in Mathematics (2014), Department of Mathematics, Sichuan University, Chengdu, China
RESEARCH INTEREST
- statistical genetics
- developing statistical and computational methods for the analysis of high-dimensional genetic data
- clinical trials
- dose-response studies, adaptive designs, repeated measures designs
PUBLICATIONS
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Cui, Y., Lin, Q., Zhou, J., Yuan, X., Ma, S.*, and Yu, Z.* (2024+) High-dimensional mediation analysis for longitudinal data. Submitted. *Co-corresponding author.
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Sun, X.#, Ma, S.#, Guo, Y.,#, Chen, C., Pan, L., Cui, Y., Chen, Z., Dijkhuizen, R. M., Zhou, Y., Boltze, J.*, Yu, Z.,* and Li, P.* (2024+) The association between air pollutant exposure and cerebral small vessel disease with modifying effects of PRS-defined genetic susceptibility. Submitted. #Co-first author.
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Yuan, X., Ma, Y., Gao, R., Cui, S., Fa, B., Wang. Y., Ma, S., Wei, T., Ma, S. and Yu, Z. (2024+) HEARTSVG: a fast and accurate method for spatially variable gene identification in large-scale spatial transcriptomic data. Submitted.
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Ma, S. and Wang, T. (2023). The optimal pre-post allocation for randomized clinical trials. BMC Medical Research Methodology, 23, 72.
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Ma, S., Wang, C., Khan, A., Liu, L., Dalgleish, J., Kiryluk, K., He, Z. and Ionita-Laza, I. (2023). BIGKnock: Fine-mapping gene-based associations via knockoff analysis of biobank-scale data. Genome Biology, 24, 24.
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He, Z., Liu, L., Belloy, M. E., Guen, Y. L., Sossin, A., Liu. X., Qi. X, Ma, S., Gyawali, P. K., Wyss-Coray, T., Tang, H., Sabatti, C., Candès, E., Greicius, M. D. and Ionita-Laza, I. (2022) GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies. Nature Communications, 13, 7209.
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Ma, S. and McDermott, M. P. (2022). Adaptive dose-response studies to establish proof-of-concept in learning-phase clinical trials. Biometrical Journal, 64(1), 146-164.
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Ma, S., Dalgleish, J., Lee, J., Wang, C., Liu, L., Gill, R., Buxbaum, J. D., Chung, W. K., Aschard, H., Silverman, E. K., Cho, M. H., He, Z. and Ionita-Laza, I. (2021). Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes. Proceedings of the National Academy of Sciences of the United States of America, 118(47), e2105191118.
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He, Z., Guen, Y. L., Liu, L., Lee, J., Ma, S., Yang, A. C., Liu. X., Rutledge, J., Losada, P. M., Song, B., Belloy, M. E., Butler, R. R., Longo, F. M., Tang, H., Mormino, E. C., Wyss-Coray, T., Greicius, M. D. and Ionita-Laza, I. (2021) Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics. American Journal of Human Genetics, 108(12), 2336-2353.
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Prasad, P., Brown, L., Ma, S., McDavid, A., Rudmann, A., Lent, D., Reagan-Webster, P., Valcin, K. E., Graman, P. and Apostolakos, M. (2021). “If the glove fits”: Hospital-wide universal gloving is associated with improved hand hygiene and may reduce Clostridioides difficile infection. Infection Control and Hospital Epidemiology, 42(11), 1351-1355.
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Ma, S. and McDermott, M. P. (2020). Generalized multiple contrast tests in dose-response studies. Statistics in Medicine, 39(6), 757-772.
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Andrzejewski, K. L., Ma, S., Owens, A., Bull, M. T., Biglan, K. M., Kanchana, S., Mink, J. W., McDermott, M. P., Crane, B. T., Barbano, R. (2018) Alterations in vestibular function in individuals with cervical dystonia and the effects of botulinum toxin treatment. Basal Ganglia, 13, 1-6.
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Schobel, S. A., Palermo, G., Auinger, P., Long, J. D., Ma, S., Khwaja, O. S., Trundell, D., Cudkowicz, M., Hersch, S., Sampaio, C., Dorsey, E. R., Leavitt, B. R., Kieburtz, K. D., Sevigny, J. J., Langbehn, D. R., Tabrizi, S. J.; TRACK-HD, COHORT, CARE-HD, and 2CARE Huntington Study Group Investigators. (2017) Motor, cognitive, and functional declines contribute to a single progressive factor in early HD. Neurology, 89(24), 2495-2502.
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Couderc, J. P., Ma, S., Page, A., Besaw, C., Xia, J., Chiu, W. B., de Bie, J., Vicente, J., Vaglio, M., Badilini, F., Babaeizadeh, S., Chien, C. S., Baumert, M. (2017) An evaluation of multiple algorithms for the measurement of the heart rate corrected JTpeak interval. Journal of Electrocardiology, 50(6), 769-775.
FUNDING (as PI)
- The National Natural Science Foundation of China Excellent Young Scholars Fund (Overseas), (2024-2026).
- Shanghai Rising-Star Program, 23YF1421000, (2023-2026).
- Clinical Research Project of Shanghai Municipal Health Commission in Health Industry, 20234Y0285, (2023-2026).
- Fundamental Research Funds for the Central Universities, YG2023QNA01, (2023-2025).
INVITED TALKS
- 12th International Conference on Bioinformatics and Computational Biology (ICBCB 2024), Tokyo, Japan (03/2024).
- Tianyuan Mathematics Research Center, Kunming, China (01/2024).
- 16th International Conference of the ERCIM WG on Computational and Methodological Statistics, Berlin, Germany (12/2023).
- Institute of Applied Mathematics, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, China (11/2023).
- Department of Biostatistics, Peking University, China (11/2023).
- Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China. (10/2023).
- Joint Conference on Statistics and Data Science in China 2023, Beijing, China (07/2023).
- The Second International Workshop on Statistical Theory and Related Fields, Tianjin, China (07/2023).
- ICSA 2023 China Conference, Chengdu, China (06/2023).
- Center for Statistical Science, Tsinghua University, China (05/2023).
- School of Mathematical Sciences, Shanghai Jiao Tong University, China (03/2023).
- Department of Biostatistics, City University of Hong Kong, China (11/2022).
- Department of Bioinformatics and Biostatistics, Shanghai Jiao Tong University, China (06/2022).
- The 34th New England Statistics Symposium, Hybrid conference, USA (10/2021).
TEACHING
- Introduction to Clinical Research Methods, Shanghai Jiao Tong University School of Medicine (November 2023)
SOFTWARE DEVELOPED
- BIGKnock: An R package of performing biobank-scale gene-based association test via knockoffs.
- GeneScan3DKnock: An R package for performing improved gene-based testing by integrating long-range chromatin interactions, along with knockoff-enhanced tests.
- GeneScan3D - UK Biobank Gene-based Results: Browser of the GeneScan3D gene-based results for 1,403 UK biobank binary phecodes, 42 BioBank Japan binary phenotypes and 5 psychiatric phenotypes.
CONTACT
227 South Chongqing Road Shanghai, 200025, China
Email: mashiyang1991@sjtu.edu.cn